Drugs for the Treatment of Respiratory Diseases

Respiratory diseases affect millions of people each year and represent a major health burden around the world. This timely reference surveys and evaluates the drug treatments available for the main categories of lung diseases including asthma, tuberculosis, chronic obstructive pulmonary disease, lung cancer, and respiratory infections. The recent re-emergence of tuberculosis and the increase in asthma in certain populations underlines the importance of finding effective new treatments for these diseases. This publication, a comprehensive reference, is one of the first to survey current and novel drug treatments for this group of diseases. It is certain to establish itself as an essential source of reference for respiratory physicians, clinicians and clinical pharmacologists.

• First comprehensive survey of established and novel drug treatments for all categories of respiratory diseases • The re-emergence and increased prevalence of some of these diseases makes this publication more timely than ever • An essential source of reference for all health professionals looking after patients with respiratory diseases

Part I. Asthma and COPD: 1. Pathology of asthma and COPD Peter K. Jeffery; 2. Glucocorticosteroids Peter J. Barnes; 3. ß2- adrenoceptor agonists Domenico Spina, Clive P. Page and Brian J. O'Connor; 4. Anticholinergic bronchodilators Jeremy M. Segal and Nicholas J. Gross; 5. Antiallergic drugs Mazakazu Ichinose; 6. Drugs affecting the synthesis and action of leukotrienes Paul M. O'Byrne; 7. Theophylline and selective phosphodiesterase inhibitors in the treatment of respiratory disease N. A. Jones, Domenico Spina and Clive P. Page; 8. Potential therapeutic effects of potassium channel openers in respiratory diseases Ahmed Z. El-Hashim; 9. Tachykinin and kinin antagonists Pierangelo Geppetti; 10. Drugs affecting IgE (synthesis inhibitors and monoclonal antibodies) Lawrence G. Garland and Alan G. Lamont; 11. Drugs targeting cell signalling Brydon L. Bennett, Yoshitaka Satoh and Alan J. Lewis; Part II. Diffuse Parenchymal Lung Disease: 12. Current approaches to the treatment of parenchymal lung diseases Joseph P. Lynch III and Michael Keane; 13. Drug treatments of the future in fibrotic lung disease Athol U. Wells; Part III. Infection: 14. Current and future management of pneumonia Mario Cazzola and Maria G. Matera; 15. Current treatment of chronic bronchial suppuration Robert Wilson; 16. Current and future treatment of cystic fibrosis R. Gary, G. Ruiz, Hilary Wyatt and John F. Price; Part IV. Pulmonary Vascular Diseases: 17. Pathophysiology of pulmonary vascular disease Sanjay Mehta and David G. McCormack; 18. Current treatment of pulmonary vascular diseases Tarek Saba and Andrew Peacock; 19. Future treatment of pulmonary vascular diseases Norbert F. Voelkel, M. W. Geraci and S. Abman; Part V. Lung Cancer:20. Molecular pathology of lung cancer Ignacio I. Wistuba and Adi F. Gazdar; 21. Small cell lung cancer Desmond N. Carney; Part VI. Cough: 22. Mechanisms of cough John J. Adcock; 23. Current treatment of cough Peter V. Dicpinigaitis.